Trisha made her debut in bollywood cinema field with the Indian famous director Priyadarshan film Khatta Meetha, alongside with Akshay Kumar. This film received nagative reviews from critics and become a Box Office failure.
In April 2011, Trisha next release Telugu movie Theenmaar with Pawan Kalyan, which was became a blockbuster. Her next movie in Tamil Leading Actor Ajith Kumar's movie Mankatha which movie has positive reviews and has become one of her biggest blockbusters till date.
In 2012, Trisha acted in Telugu movie Bodyguard, opposite Telugu leading actor Venkatesh and it was also a super hit, which film was a remake of the Malayalam language movie Bodyguard. Next, She acted in Telugu movie Dammu as a leading female role, alongside with Jr.NTR as an above average box office collection.
In 2013, Trisha return to Tamil movie "Samar" opposite Vishal, which movie has positive reviews from critics and average hit. Recently, Trisha is acting alongside Jayam Ravi in Tamil movie Boologam and Jeeva in Endrendrum Punnagai which are currently in production and are movie release scheduled as 2013 or 2014.