
His first release in 2006 was Kalvanin Kadhali. Indiaglitz.com described her performance as " the strength of the film." She next made her debut in Telugu, starring in the film Lakshmi, following which is held in chief, I Love You, alongside Venkatesh and Nagarjuna respectively.
Three Tamil films in which She passed the lead female characters - Vallavan, Thalaimagan and E - were released simultaneously during Diwali 2006. All three films opened to mixed reviews ; most Nayantara won praise for their performances.

The sci-fi thriller E Nayantara appears in the role of a bar dancer. Reviewers state that made an impact was " very appropriate and impressive on paper a little complicated ," and that "they had come up with a good performance."